The priming of naive T cells requires antigen presentation by activated dendritic cells, yet the optimal generation of effector and memory CD8+ T cells requires subsequent T cell–T cell interactions during the critical differentiation period.
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References
Gérard, A. et al. Nat. Immunol. 14, 356–363 (2013).
Rothlein, R., Dustin, M.L., Marlin, S.D. & Springer, T.A. J. Immunol. 137, 1270–1274 (1986).
Katz, F.E. et al. Eur. J. Immunol. 15, 103–106 (1985).
Chang, J.T. et al. Science 315, 1687–1691 (2007).
Scholer, A., Hugues, S., Boissonnas, A., Fetler, L. & Amigorena, S. Immunity 28, 258–270 (2008).
Sabatos, C.A. et al. Immunity 29, 238–248 (2008).
Mempel, T.R., Henrickson, S.E. & Von Andrian, U.H. Nature 427, 154–159 (2004).
Blair, D.A. et al. J. Immunol. 187, 2310–2321 (2011).
Obst, R., van Santen, H.M., Mathis, D. & Benoist, C. J. Exp. Med. 201, 1555–1565 (2005).
Wherry, E.J. et al. Nat. Immunol. 4, 225–234 (2003).
Cox, M.A., Barnum, S.R., Bullard, D.C. & Zajac, A.J. Proc. Natl. Acad. Sci. USA 110, 1416–1421 (2013).
Somersalo, K. et al. J. Clin. Invest. 113, 49–57 (2004).
Thaventhiran, J.E. et al. Proc. Natl. Acad. Sci. USA 109, E2223–E2229 (2012).
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Blair, D., Dustin, M. T cell priming goes through a new phase. Nat Immunol 14, 311–312 (2013). https://doi.org/10.1038/ni.2575
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DOI: https://doi.org/10.1038/ni.2575