Supplementary Figure 6: Post-thymic ThPOK restrains cytotoxic gene expression during in vivo TH1 responses. | Nature Immunology

Supplementary Figure 6: Post-thymic ThPOK restrains cytotoxic gene expression during in vivo TH1 responses.

From: A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells

Supplementary Figure 6

(a) Contour plots assess uninfected (left) or day 10-infected (right) Thpok+/+ or Thpokpd spleen CD4+ T cells for expression of intra-cellular IFN-γ versus IL-17A. (b) Parasite load was quantified as percentage of RFP+ splenocytes in mice infected with RFP-expressing T. gondii. Each symbol represents one mouse; data are from two independent experiments. No significant difference by t-test. (c) Contour plots of Eomes versus T-bet expression in spleen CD4+ T cells from uninfected (left) or day 10-infected (right) Thpok+/+ or Thpokpd mice. Data (a,c) are representative of three experiments for each panel.

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