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Neutrophils worm their way into macrophage long-term memory

Neutrophil function is perhaps best studied in bacterial infection, during which they are directly involved in pathogen killing. After helminth invasion, however, neutrophils acquire an alternative transcriptional profile that allows them to 'train' macrophages to acquire long-term protective features.

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Figure 1: Neutrophils 'train' lung macrophages to take on features that protect against helminth larvae during secondary infection.

Kim Caesar/Nature Publishing Group

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Correspondence to John R Grainger or Richard K Grencis.

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Grainger, J., Grencis, R. Neutrophils worm their way into macrophage long-term memory. Nat Immunol 15, 902–904 (2014). https://doi.org/10.1038/ni.2990

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