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2 methylate or not 2 methylate: viral evasion of the type I interferon response

Nature Immunology volume 12, pages 114–115 (2011)Cite this article

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Recent work highlights the requirement for 2′-O-methylation of capped mRNA to prevent recognition by the antiviral host response.

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Figure 1: 2′-O-methylation of viral mRNA avoids recognition by the cellular antiviral sensing machinery.

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Authors and Affiliations

  1. Adolfo García-Sastre is at the Department of Microbiology, the Department of Medicine, Division of Infectious Diseases, and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, USA.,

    Adolfo García-Sastre

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  1. Adolfo García-Sastre
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Correspondence to Adolfo García-Sastre.

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The author declares no competing financial interests.

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García-Sastre, A. 2 methylate or not 2 methylate: viral evasion of the type I interferon response. Nat Immunol 12, 114–115 (2011). https://doi.org/10.1038/ni0211-114

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