Although it often acts as a transcriptional activator, the nuclear hormone receptor PPAR-γ also 'transrepresses' inflammatory responses mediated by the transcription factor NF-κB. New data demonstrate that sumoylation of PPAR-γ leads to the retention of repressor complexes on promoters of inflammatory genes.
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Bailey, S., Ghosh, S. 'PPAR'ting ways with inflammation. Nat Immunol 6, 966–967 (2005). https://doi.org/10.1038/ni1005-966
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DOI: https://doi.org/10.1038/ni1005-966
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