Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunity or tolerance? That is the question for dendritic cells

Nature Immunology volume 2, pages 988–989 (2001) Cite this article

The “two-signal” model proposes that immature DCs that deliver signal 1 in the absence of signal 2 cross-tolerize CD8+ T cells. New evidence shows that mature DCs are required for both cross-tolerance and cross-priming.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A maturing DC, captured after exit from mouse ear skin.
The alternative text for this image may have been generated using AI.

Jose Villadangos

References

  1. Mellman, I. & Steinman, R. M. Cell 106, 255–258 (2001).

    Article  CAS  Google Scholar 

  2. Albert, M. L., Jegathesan, M. & Darnell, R. B. Nature Immunol. 2, 1010–1017 (2001).

    Article  CAS  Google Scholar 

  3. Kurts, C., Kosaka, H., Carbone, F. R., Miller, J. F. & Heath, W. R. J. Exp. Med. 186, 239–245 (1997).

    Article  CAS  Google Scholar 

  4. Heath, W. R. & Carbone, F. R. Annu. Rev. Immunol. 19, 47–64 (2001).

    Article  CAS  Google Scholar 

  5. Bennett, S. R. et al. Nature 393, 478–480 (1998).

    Article  CAS  Google Scholar 

  6. de St Groth, B. Immunol. Today 19, 448–254 (1998).

    Article  CAS  Google Scholar 

  7. Süss, G. & Shortman, K. J. Exp. Med. 183, 1789–1796 (1996).

    Article  Google Scholar 

  8. Kamath, A. et al. J. Immunol. 165, 6762–6770 (2000).

    Article  CAS  Google Scholar 

  9. Bennett, S. R., Carbone, F. R., Karamalis, F., Miller, J. F. & Heath, W. R. J. Exp. Med. 186, 65–70 (1997).

    Article  CAS  Google Scholar 

  10. Ridge, J. P., Di Rosa, F. & Matzinger, P. Nature 393, 474–478 (1998).

    Article  CAS  Google Scholar 

  11. Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R. & Melief, C. J. Nature 393, 480–483 (1998).

    Article  CAS  Google Scholar 

  12. Guerder, S. & Matzinger, P. J. Exp. Med. 176, 553–564 (1992).

    Article  CAS  Google Scholar 

  13. Adler, A. J. et al. J. Exp. Med. 187, 1555–1564 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

    Ken Shortman & William R. Heath

Authors
  1. Ken Shortman
    View author publications

    Search author on:PubMed Google Scholar

  2. William R. Heath
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shortman, K., Heath, W. Immunity or tolerance? That is the question for dendritic cells. Nat Immunol 2, 988–989 (2001). https://doi.org/10.1038/ni1101-988

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/ni1101-988

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing