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Macrophage tolerance: CD47–SIRP-α–mediated signals matter

Nature Immunology volume 8, pages 1287–1289 (2007)Cite this article

Inhibition of phagocyte activity depends on the ligation of SIRP-α by CD47. New findings show that Sirpa polymorphisms influence the engraftment and tolerance of xenogeneic transplants in NOD-SCID mice.

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Figure 1: The interactions of innate and adaptive immune cells of the recipient organism with transplanted donor cells.

Kim Caesar

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Authors and Affiliations

  1. Hitoshi Takizawa is with the Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland.,

    Hitoshi Takizawa

  2. Markus G. Manz is with the Institute for Research in Biomedicine and the Department of Hematology, Oncology Institute of Southern Switzerland, Ospedale San Giovanni, CH-6500 Bellinzona, Switzerland. manz@irb.unisi.ch,

    Markus G Manz

Authors
  1. Hitoshi Takizawa
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  2. Markus G Manz
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Takizawa, H., Manz, M. Macrophage tolerance: CD47–SIRP-α–mediated signals matter. Nat Immunol 8, 1287–1289 (2007). https://doi.org/10.1038/ni1207-1287

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