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Genomics

Native chromosome conformation

Isolation of nuclei in an isotonic buffer retains chromosome loops and allows the probing of intrinsic loop conformation.

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References

  1. Brant, L. et al. Exploiting native forces to capture chromosome conformation in mammalian cell nuclei. Mol. Syst. Biol. 12, 891 (2016).

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Rusk, N. Native chromosome conformation. Nat Methods 14, 105 (2017). https://doi.org/10.1038/nmeth.4172

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