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How do your prions grow?

Abstract

A system for the rapid amplification of misfolded prion oligomers provides new evidence supporting the prion hypothesis and may offer a powerful diagnostic tool.

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References

  1. Saborio, G.P. et al. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411, 810–813 (2001).

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  2. Castilla, J. et al. In vitro generation of infectious scrapie prions. Cell 121, 195–206 (2005).

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Eisenstein, M. How do your prions grow?. Nat Methods 2, 410 (2005). https://doi.org/10.1038/nmeth0605-410b

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  • DOI: https://doi.org/10.1038/nmeth0605-410b

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