Abstract
A system for the rapid amplification of misfolded prion oligomers provides new evidence supporting the prion hypothesis and may offer a powerful diagnostic tool.
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References
Saborio, G.P. et al. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411, 810–813 (2001).
Castilla, J. et al. In vitro generation of infectious scrapie prions. Cell 121, 195–206 (2005).
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Eisenstein, M. How do your prions grow?. Nat Methods 2, 410 (2005). https://doi.org/10.1038/nmeth0605-410b
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DOI: https://doi.org/10.1038/nmeth0605-410b