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Hepatitis C virus's next top models?

Nature Microbiology volume 1, Article number: 15018 (2016) Cite this article

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Advances in culturing hepatitis C virus have given hope for a universal cell culture system amenable to primary isolate replication. However, low replication efficiency needs to be overcome. The development of fully susceptible yet immunocompetent in vivo models would aid research towards a prophylactic vaccine.

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Figure 1: Model systems for the study of HCV in vitro and in vivo.

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Authors and Affiliations

  1. David Paul and Ralf Bartenschlager are in the Department of Infectious Diseases, Molecular Virology, University of Heidelberg, 69120 Heidelberg, Germany.,

    David Paul & Ralf Bartenschlager

  2. Ralf Bartenschlager is also in the Division of Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.,

    Ralf Bartenschlager

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  1. David Paul
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  2. Ralf Bartenschlager
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Correspondence to Ralf Bartenschlager.

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Paul, D., Bartenschlager, R. Hepatitis C virus's next top models?. Nat Microbiol 1, 15018 (2016). https://doi.org/10.1038/nmicrobiol.2015.18

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