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Mobile binding sites regulate glutamate clearance

Nature Neuroscience volume 18, pages 166–168 (2015)Cite this article

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Glutamate transporters influence the kinetics of synaptic transmission by acutely buffering synaptically released glutamate. In addition to high synaptic density of EAAT2, the transporter's high mobility contributes to function.

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Figure 1: The glial glutamate transporter EAAT2 appears to be concentrated near synapses, where it acts acutely to shape synaptic transmission by binding released glutamate.

Katie Vicari/Nature Publishing Group

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  1. Robert H. Edwards is in the Departments of Physiology and Neurology, University of California, San Francisco, San Francisco, California, USA.,

    Robert H Edwards

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  1. Robert H Edwards
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Correspondence to Robert H Edwards.

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The author declares no competing financial interests.

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Edwards, R. Mobile binding sites regulate glutamate clearance. Nat Neurosci 18, 166–168 (2015). https://doi.org/10.1038/nn.3931

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