Neurofibromatosis type I is often associated with learning disabilities. Recent work shows that lack of neurofibromin impairs memory because overactive ERK signaling in hippocampal interneurons causes excessive GABA release.
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Staley, K., Anderson, A. Hyperactive interneurons impair learning in a neurofibromatosis model. Nat Neurosci 12, 8–10 (2009). https://doi.org/10.1038/nn0109-8
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DOI: https://doi.org/10.1038/nn0109-8
