Figure 1

Correlation between disease duration and important clinical features. The correlation between disease duration and the latency of down-gaze palsy (top left panel, in 7 patients with down-gaze palsy before death, with Pearson’s correlation coefficient r=0.902, P=0.005; and top right panel, in 10 patients including the 3 patients without down-gaze palsy in life, taking the duration of the disease as the latency in these 3 patients, with r=0.8893, P=0.001), MMSE score at first visit (on average the first 2.7 years after disease onset, mid left panel, r=0.920, P=0.009) and the latency of dysautonomia (mid right panel, r=0.752, P=0.031) in PSP; and the latency of falls (bottom left panel, r=0.675, P=0.016) and WCB (wheel chair bound, bottom right panel, r=0.990, P=0.010) in MSA.