Table 2 Loss of function of specific genes was predicted to arrest the cell cycle at different phases

From: A method to identify and analyze biological programs through automated reasoning

Mutant

Prediction

Experimental Support

Reference (SGD ID)

Cln3

Prevents transition from Start to G1

Incorrect prediction: Cln3 knockdown is found to lead to increased G1 duration

S000000038

MBF or SBF

Prevents transition from G1 to S

Either MBF or SBF knockdown leads to increased g1 duration

S000004172

Clb56 or SBF

Prevents transition from S to G2

Clb56 knockdown causes a delay in the progression through S phase

S000006324

Clb12 or SBF

Prevents transition from G2 to M

(1) SBF knockdown leads to delayed G2/M transition

(1) S000000913

  

(2) Clb12 knockdown delays progression through M phase

(2) S000006323

Cdc20

Prevents transition from M to G0

Cdc20 knockdown delays progression through M phase

S000003084

  1. Experimental support for these predictions has been found through the Saccharomyces Genome Database (www.yeastgenome.org). Only one prediction was found to be incorrect (Cln3 mutant).
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