Table 1 Frequency of drug prescribing

Drug	Proportion of all patients prescribed drug at some point during the study period (%)	Median daily dose (for drugs taken by ≥5% of patients)	Minimum effective daily dose ³² , where established
First-generation antipsychotics
Chlorpromazine	12.0	150 mg	200 mg³³^a
Flupentixol	15.7	6 mg	?^34,35
Fluphenazine	4.0	–	–
Haloperidol	20.1	10 mg	4 mg³²
Levomepromazine	0.1	–	–
Pericyazine	0.1	–	–
Perphenazine	0.1	–	–
Pimozide	0.7	–	–
Pipotiazine	5.1	7.1 mg	21 mg³⁶^a
Prochlorperazine	0.5	–	–
Promazine	0.4	–	–
Sulpiride	5.7	400 mg	400 mg³³^a
Trifluoperazine	7.5	10 mg	10 mg³³^a
Zuclopenthixol	8.8	37.9 mg	14 mg³⁷^a
Second-generation antipsychotics
Amisulpride	15.5	400 mg	400 mg³³^a
Aripiprazole	16.8	15 mg	10 mg³²
Asenapine	0.1	–	–
Clozapine	27.1	250 mg ^b	300 mg³²
Olanzapine	39.3	12.5 mg	7.5 mg³²
Paliperidone	2.4	–	–
Quetiapine	17.6	300 mg	150 mg³²
Risperidone	31.9	3.6 mg	2 mg³²
Antidepressants used by ≥5% of patients
Citalopram	15.2	20 mg	20 mg³³
Fluoxetine	10.8	20 mg	20 mg³³
Mirtazapine	10.0	30 mg	30 mg³³
Sertraline	7.3	100 mg	50 mg³³
Venlafaxine	5.9	150 mg	75 mg³³

Second-generation antipsychotics (SGAs) were in general used more than first-generation antipsychotics (FGAs), except for relatively frequent use of haloperidol (which is often prescribed ‘as required’ in this institution). The FGA benperidol and the SGAs iloperidone, lurasidone, sertindole, ziprasidone, and zotepine were not used. The percentages of patients prescribed a depot medication at some point were: FGAs: haloperidol 2.1%, flupentixol 12.8%, fluphenazine 3.2%, paliperidone 2.4%, pipotiazine 5.1%, zuclopenthixol 1.6%; SGAs: olanzapine 0.1%, and risperidone 6.6%.
^aEstimate.
^bClozapine doses were in some cases electronically underestimated as this is a drug whose dose is split across the day; for example, ‘clozapine 200 mg in the morning, 200 mg at night’ was misinterpreted as 200 mg/day.

Search