Figure 5
From: STAT1 Negatively Regulates Spatial Memory Formation and Mediates the Memory-Impairing Effect of Aβ
Both signal transducer and activator of transcription-1 (STAT1) and laminin β1 (LB1) mediate the memory-impairing effect of Aβ. Rats received Aβ+STAT1 siRNA transfection, Aβ+control siRNA transfection, or NH4OH+control siRNA transfection and were subject to (a) water maze learning and (b) probe trial test. (c) Gel pattern and analysis of STAT1 and LB1 protein expression after the probe trial test. A separate group of rats received Aβ+LB1 siRNA transfection, Aβ+control siRNA transfection, or NH4OH+control siRNA transfection and were subject to (d) water maze learning and (e) probe trial test. (f) Gel pattern and analysis of STAT1 and LB1 protein expression after the probe trial test. Data are mean±SEM. *P<0.05 and #P<0.001. a: compared with the corresponding Aβ+control siRNA group.
