Figure 1 | Neuropsychopharmacology

Figure 1

From: Eating ‘Junk-Food’ Produces Rapid and Long-Lasting Increases in NAc CP-AMPA Receptors: Implications for Enhanced Cue-Induced Motivation and Food Addiction

Figure 1

GluA1, but not GluA2, surface expression is greater in Junk-Food-Gainers than Non-Gainers. (a) Junk-food produces substantial weight gain in a subset of susceptible rats. (b) Eating junk-food followed by junk-food deprivation is associated with a sensitized response to cocaine in Junk-Food-Gainers (JF-G) compared with Junk-Food-Non-Gainers (JF-N). Inset shows locomotion during habituation and after saline injection. (c) Representative blot of GluA1 expression in crosslinked NAc samples. (d, e) GluA1, but not GluA2, surface expression is greater in Junk-Food-Gainers compared with Junk-Food-Non-Gainers after junk-food deprivation, suggesting the presence of CP-AMPARs. All data are shown as mean±SEM; *p<0.05.

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