Figure 2 | Neuropsychopharmacology

Figure 2

From: Eating ‘Junk-Food’ Produces Rapid and Long-Lasting Increases in NAc CP-AMPA Receptors: Implications for Enhanced Cue-Induced Motivation and Food Addiction

Figure 2

The contribution of CP-AMPARs is greater in Junk-Food-Gainer vs chow-fed rats following junk-food deprivation. (a) Normalized amplitude before (BL) and after bath application of the CP-AMPAR antagonist naspm (200 μM). Inset shows example eEPSCs before (black) and after naspm (red). (b) The reduction by naspm is greater in Junk-Food-Gainer vs chow-fed rats. (c) Location of whole-cell recordings for all experiments. The shaded area indicates the general location of recordings made in the NAc core. Recordings fell approximately between 2.04 and 1.56 mm from Bregma; figure adapted from Paxinos and Watson (2007). All data shown as mean±SEM; *p<0.05. A full color version of this figure is available at the Neuropsychopharmacology journal online.

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