Figure 4
Just 10 days of junk-food followed by 2 weeks of junk-food deprivation is sufficient to induce CP-AMPAR upregulation in obesity-prone but not obesity-resistant rats. This increase occurred in the absence of differences in food intake and weight gain. (a) Normalized amplitude before and after naspm (200 μM). Inset: Example of eEPSCs from junk-food fed rats before (black) and after naspm (red). (b) Time course of eEPSC before and after naspm application. (c) The reduction by naspm is increased after junk-food in obesity-prone but not obesity-resistant rats. (d) Weight gain is similar between groups. (e) Junk-food consumption is similar between groups. All data shown as mean±SEM. *p<0.05; ***p<0.001 OP-JF vs all other groups. A full color version of this figure is available at the Neuropsychopharmacology journal online.
