Figure 5
Junk-food-induced increases in CP-AMPARs are present after just 1 day of junk-food deprivation in obesity-prone but not obesity-resistant rats. (a) Normalized amplitude before (Baseline) and after naspm (200 μM). Inset: Example eEPSCs from junk-food fed rats before (black) and after naspm (red). (b) Time course before and after naspm application. (c) The reduction by naspm is greater in obesity-prone vs obesity-resistant rats given junk-food. (d) Weight gain is similar between groups. (e) Junk-food consumption is similar between groups. All data are shown as mean±SEM. * = p<0.05, **p<0.01. (f) Summary of individual eEPSC amplitudes across all studies (BL=baseline, N= + naspm; open symbols=chow groups, closed symbols=junk-food groups, triangles=outbred rats, circles=obesity-resistant rats, and squares=obesity-prone rats). A full color version of this figure is available at the Neuropsychopharmacology journal online.
