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Coronary artery disease

Diagnostic blood test validated

Nature Reviews Cardiology volume 7, page 665 (2010)Cite this article

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A blood-based gene expression test developed to aid in the diagnosis of coronary artery disease (CAD) has now been prospectively validated in the multicenter PREDICT trial. According to Dr Eric Topol, one of the PREDICT investigators, “the test, which is commercially available, can be used to help decide whether to go to angiography, when there are uncertainties.”

Patients who are suspected of having CAD often undergo a diagnostic coronary angiogram. As Dr Topol explains, however, “there is a high rate of normal angiograms—about 30%”. Given the invasive nature of coronary angiograms, the PREDICT investigators aimed to develop a gene expression test to help diagnose obstructive CAD and reduce the number of angiograms undertaken.

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ORIGINAL RESEARCH PAPER

  1. Rosenberg, S. et al. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann. Intern. Med. 153, 425–434 (2010)

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  1. Bryony M. Mearns
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Mearns, B. Diagnostic blood test validated. Nat Rev Cardiol 7, 665 (2010). https://doi.org/10.1038/nrcardio.2010.172

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