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Hypertension

Risk of gout differs according to type of antihypertensive drug used

Nature Reviews Cardiology volume 9, page 127 (2012)Cite this article

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Various antihypertensive agents have been shown to alter serum levels of uric acid. To compare the risk of incident gout for a range of antihypertensive agents, Professor Hyon Choi and colleagues performed a population-based, nested case–control study using a general-practice database from the UK.

In total, data for 24,768 adults who had incident cases of gout and 50,000 randomly selected controls (matched according to age, sex, and calendar year) were assessed. After adjustment for various covariates—age, sex, calendar year, visits to general practitioner, BMI, alcohol use, smoking status, ischemic heart disease, hypertension, hyperlipidemia, and renal failure—incident gout was found to be 1.75 times more likely (95% CI 1.69–1.82) among individuals with hypertension than among individuals without hypertension.

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ORIGINAL RESEARCH PAPER

  1. Choi, H. K. et al. Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case–control study. BMJ 344, d8190 (2012)

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  1. Bryony M. Mearns
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Mearns, B. Risk of gout differs according to type of antihypertensive drug used. Nat Rev Cardiol 9, 127 (2012). https://doi.org/10.1038/nrcardio.2012.8

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