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Anticoagulation therapy

Sulodexide reduces the risk of recurrent venous thromboembolism

Nature Reviews Cardiology volume 12, page 682 (2015)Cite this article

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Administration of sulodexide after discontinuation of anticoagulant treatment in patients with unprovoked venous thromboembolism significantly reduced the incidence of recurrences, and did not increase the risk of bleeding events. These findings come from the SURVET study, a randomised controlled double-blind trial that assessed the safety and efficacy of this natural glycosaminoglycan in preventing the recurrence of venous thromboembolism once standard anticoagulation treatment has been discontinued.

The risk of recurrence is particularly high in patients with a first episode of unprovoked venous thromboembolism. Although extending anticoagulant therapy can reduce the risk of recurrence, it is also associated with increased bleeding, emphasizing the need to find alternative drugs. Sulodexide, which has antithrombotic and profibrinolytic activities, has been previously shown to be associated with very low risk of bleeding and is approved in some countries for the treatment of chronic venous diseases.

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References

  1. Andreozzi, G. M. et al. Sulodexide for the Prevention of Recurrent Venous Thromboembolism: the SURVET Study: a multicenter, randomized, double-blind, placebo controlled trial. Circulation 10.1161/CIRCULATIONAHA.115.016930

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Authors
  1. Irene Fernández Ruiz
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Ruiz, I. Sulodexide reduces the risk of recurrent venous thromboembolism. Nat Rev Cardiol 12, 682 (2015). https://doi.org/10.1038/nrcardio.2015.163

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