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Stem cells

The cancer's gone, but did chemotherapy damage your heart?

Nature Reviews Cardiology volume 13, pages 383–384 (2016)Cite this article

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Many patients who undergo doxorubicin chemotherapy develop cardiac complications later in life. Patient-derived cardiomyocytes can be used to predict individual susceptibility to drug-induced cardiotoxicity, as evidenced by enhanced doxorubicin responses in cardiomyocytes derived from induced pluripotent stem cells of patients who developed heart failure after chemotherapy.

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Figure 1: Role of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in cardio-oncology and precision medicine.

References

  1. Giordano, S. H., Lin, Y. L., Kuo, Y. F., Hortobagyi, G. N. & Goodwin, J. S. Decline in the use of anthracyclines for breast cancer. J. Clin. Oncol. 30, 2232–2239 (2012).

    Article  CAS  Google Scholar 

  2. Saeed, M. F., Premecz, S., Goyal, V., Singal, P. K. & Jassal, D. S. Catching broken hearts: pre-clinical detection of doxorubicin and trastuzumab mediated cardiac dysfunction in the breast cancer setting. Can. J. Physiol. Pharmacol. 92, 546–550 (2014).

    Article  CAS  Google Scholar 

  3. Ghigo, A., Li, M. & Hirsch, E. New signal transduction paradigms in anthracycline-induced cardiotoxicity. Biochim. Biophys. Acta. http://dx.doi.org/10.1016/j.bbamcr.2016.01.021 (2016).

  4. Burridge, P. W. et al. Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nat. Med. 22, 547–556 (2016).

    Article  CAS  Google Scholar 

  5. Singal, P. K. & Iliskovic, N. Doxorubicin-induced cardiomyopathy. N. Engl. J. Med. 339, 900–905 (1998).

    Article  CAS  Google Scholar 

  6. Rouhani, F. et al. Genetic background drives transcriptional variation in human induced pluripotent stem cells. PLoS Genet. 10, e1004432 (2014).

    Article  Google Scholar 

  7. Brown, S. A., Sandhu, N. & Herrmann, J. Systems biology approaches to adverse drug effects: the example of cardio-oncology. Nat. Rev. Clin. Oncol. 12, 718–731 (2015).

    Article  CAS  Google Scholar 

  8. Collins, F. S. & Varmus, H. A new initiative on precision medicine. N. Engl. J. Med. 372, 793–795 (2015).

    Article  CAS  Google Scholar 

  9. Veerman, C. C. et al. Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem? Stem Cells Dev. 24, 1035–1052 (2015).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank Luca Sala (Leiden University Medical Center, Netherlands) for his contribution to discussion of the content in this article. C.L.M. is supported by the European Research Council Advanced Grant STEMCARDIOVASC.

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  1. Milena Bellin and Christine L. Mummery are at the Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, Netherlands,

    Milena Bellin & Christine L. Mummery

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  1. Milena Bellin
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  2. Christine L. Mummery
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Correspondence to Christine L. Mummery.

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Competing interests

C.L.M. is co-founder of Pluriomics. M.B. declares no competing interests.

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Bellin, M., Mummery, C. The cancer's gone, but did chemotherapy damage your heart?. Nat Rev Cardiol 13, 383–384 (2016). https://doi.org/10.1038/nrcardio.2016.88

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