Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Radiotherapy

Effect of treatment interruptions in prostate cancer

Nature Reviews Clinical Oncology volume 6, pages 312–313 (2009)Cite this article

Treatment interruptions during radiotherapy may have a negative effect on patient outcome. D'Ambrosio et al. demonstrated that prolonging treatment duration has an adverse effect in low-risk patients with prostate cancer. Thus, limiting or modifying the overall elapsed time between treatments is necessary.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Maciejewski, B., Withers, H. R., Taylor, J. M. & Hliniak, A. Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx: tumor dose-response and repopulation. Int. J. Radiat. Oncol. Biol. Phys. 16, 831–843 (1989).

    Article  CAS  Google Scholar 

  2. Suwinski, R. et al. Time factor in postoperative radiotherapy: a multivariate locoregional control analysis in 868 patients. Int. J. Radiat. Oncol. Biol. Phys. 56, 399–412 (2003).

    Article  Google Scholar 

  3. Lai, P. P., Perez, C. A., Shapiro, S. J. & Lockett, M. A. Carcinoma of the prostate stage B and C: lack of influence of duration of radiotherapy on tumor control and treatment morbidity. Int. J. Radiat. Oncol. Biol. Phys. 19, 561–568 (1990).

    Article  CAS  Google Scholar 

  4. Amdur, R. J., Parsons, J. T., Fitzgerald, L. T. & Million, R. R. The effect of overall treatment time on local control in patients with adenocarcinoma of the prostate treated with radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 19, 1377–1382 (1990).

    Article  CAS  Google Scholar 

  5. D'Ambrosio, D. J. et al. Does treatment duration affect outcome after radiotherapy for prostate cancer? Int. J. Radiat. Oncol. Biol. Phys. 72, 1402–1407 (2008).

    Article  Google Scholar 

  6. Fowler, J. F. Biological factors influencing optimum fractionation in radiation therapy. Acta Oncol. 40, 712–717 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, M.D. Anderson Cancer Center, Orlando, FL, USA

    Patrick Kupelian

Authors
  1. Patrick Kupelian
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Patrick Kupelian.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kupelian, P. Effect of treatment interruptions in prostate cancer. Nat Rev Clin Oncol 6, 312–313 (2009). https://doi.org/10.1038/nrclinonc.2009.71

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nrclinonc.2009.71

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing