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Prostate cancer

Muddying the waters by overlooking treatment modality

Although large, population-based studies are a powerful tool for elucidating real-world outcomes and uncommon events, confounding factors must be tightly controlled. A recent report from Nam and coauthors has neglected such a confounding factor and, therefore, stands in need of further study to clarify the findings.

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References

  1. Nam, R. K. et al. Incidence of complications other than urinary incontinence or erectile dysfunction after radical prostatectomy or radiotherapy for prostate cancer: a population-based cohort study. Lancet Oncol. 15, 223–231 (2014).

    Article  Google Scholar 

  2. Sanda, M. G. et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N. Engl. J. Med. 358, 1250–1561 (2008).

    Article  CAS  Google Scholar 

  3. Wong, W. W. et al. Radiation dose escalation for localized prostate cancer: intensity-modulated radiotherapy versus permanent transperineal brachytherapy. Cancer 115, 5596–5606 (2009).

    Article  CAS  Google Scholar 

  4. Mohammed, N. et al. Comparison of acute and late toxicities for three modern high-dose radiation treatment techniques for localized prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 82, 204–212 (2012).

    Article  Google Scholar 

  5. Jüni, P. et al. Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet 364, 2021–2029 (2004).

    Article  Google Scholar 

  6. Vickers, A. J. et al. The surgical learning curve for prostate cancer control after radical prostatectomy. J. Natl Cancer Inst. 99, 1171–1177 (2007).

    Article  Google Scholar 

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Correspondence to Ronald D. Ennis.

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The authors declare no competing financial interests.

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Ennis, R., Quinn, S. Muddying the waters by overlooking treatment modality. Nat Rev Clin Oncol 11, 305–307 (2014). https://doi.org/10.1038/nrclinonc.2014.52

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