Although large, population-based studies are a powerful tool for elucidating real-world outcomes and uncommon events, confounding factors must be tightly controlled. A recent report from Nam and coauthors has neglected such a confounding factor and, therefore, stands in need of further study to clarify the findings.
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References
Nam, R. K. et al. Incidence of complications other than urinary incontinence or erectile dysfunction after radical prostatectomy or radiotherapy for prostate cancer: a population-based cohort study. Lancet Oncol. 15, 223–231 (2014).
Sanda, M. G. et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N. Engl. J. Med. 358, 1250–1561 (2008).
Wong, W. W. et al. Radiation dose escalation for localized prostate cancer: intensity-modulated radiotherapy versus permanent transperineal brachytherapy. Cancer 115, 5596–5606 (2009).
Mohammed, N. et al. Comparison of acute and late toxicities for three modern high-dose radiation treatment techniques for localized prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 82, 204–212 (2012).
Jüni, P. et al. Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet 364, 2021–2029 (2004).
Vickers, A. J. et al. The surgical learning curve for prostate cancer control after radical prostatectomy. J. Natl Cancer Inst. 99, 1171–1177 (2007).
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Ennis, R., Quinn, S. Muddying the waters by overlooking treatment modality. Nat Rev Clin Oncol 11, 305–307 (2014). https://doi.org/10.1038/nrclinonc.2014.52
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DOI: https://doi.org/10.1038/nrclinonc.2014.52