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Infectious diseases

Vaccine for Middle East respiratory syndrome

Nature Reviews Drug Discovery volume 14, page 679 (2015)Cite this article

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MERS-CoV is an emerging coronavirus that is distinct from the severe acute respiratory syndrome (SARS)-CoV and shows high levels of genetic diversity. It has been linked with about 495 deaths in the Arabian Peninsula, Europe and the United States, and human-to-human transmission has been documented. The syndrome presents as an acute lower respiratory tract infection that can cause severe pneumonia.

For the current study, Muthumani et al. focused on the S protein of CoV, which is the main envelope protein on the surface of the virus. To generate the consensus sequence for the vaccine, the team analysed the S protein genomic sequences contained in the GenBank database of the US National Institutes of Health. The construct design included sequences from CoV clades A and B, to help ensure broad coverage, as well as modifications to increase in vivo expression.

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References

  1. Muthumani, K. et al. A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates. Sci. Transl Med. 7, 301ra132 (2015)

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  1. Katie Kingwell
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Kingwell, K. Vaccine for Middle East respiratory syndrome. Nat Rev Drug Discov 14, 679 (2015). https://doi.org/10.1038/nrd4746

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