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Inflammatory disorders

Blocking periodontal bone loss

Nature Reviews Drug Discovery volume 14, page 820 (2015)Cite this article

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Periodontitis is a chronic inflammatory disease that causes destruction of the bone supporting the teeth, and it is often unresponsive to existing treatment. Shin et al. demonstrate that developmental endothelial locus 1 (DEL1) — an endothelial cell-secreted protein known to control unwanted inflammatory responses — is also expressed by human and mouse osteoclasts, regulating their differentiation and resorptive function by inhibiting expression of the osteoclastogenic factor nuclear factor of activated T cells cytoplasmic 1 (NFATC1). Locally administered human DEL1 blocked inflammatory bone loss in a monkey periodontitis model.

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References

  1. Shin, J. et al. DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates. Sci. Transl. Med. 7, 307ra155 (2015)

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  1. Sarah Crunkhorn
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Crunkhorn, S. Blocking periodontal bone loss. Nat Rev Drug Discov 14, 820 (2015). https://doi.org/10.1038/nrd4800

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