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Quantitative traits

Gender inequalities

Nature Reviews Genetics volume 12, page 667 (2011)Cite this article

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In this systematic survey, fasting serum concentrations of 131 metabolites were examined in >3,300 individuals from KORA F4, a German population cohort. Linear regression analysis showed that sex accounted for differences between men and women in the concentration of each of 102 of these metabolites, an effect that was replicated in a smaller population (KORA F3). In each case, sex specificity was not affected by adjusting the data for covariates such as smoking or type 2 diabetes.

Correlation patterns in the metabolic network were broadly consistent with the subdivision of the metabolites into five chemically distinct subgroups. For example, metabolites from the same subgroup were more likely to be higher in one sex than in the other.

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ORIGINAL RESEARCH PAPER

  1. Mittelstrass, K. et al. Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet. 7, e1002215 (2011)

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  1. Tanita Casci
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Casci, T. Gender inequalities. Nat Rev Genet 12, 667 (2011). https://doi.org/10.1038/nrg3071

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