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NAFLD

The role of exercise in treating NAFLD

The prevalence of NAFLD continues to increase in conjunction with sedentary lifestyles and nutrient-poor, calorie-rich diets. Given the recognized risks associated with NAFLD, effective interventions for prevention and treatment of this disease are needed. Increased exercise duration and intensity has been evaluated as an important therapeutic intervention.

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References

  1. Kistler, K. D. et al. Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. Am. J. Gastroenterol. 106, 460–468 (2011).

    Article  Google Scholar 

  2. Johnson, N. A., Keating, S. E. & George, J. Exercise and the liver: implications for therapy in fatty liver disorders. Semin. Liver Dis. 32, 65–79 (2012).

    Article  CAS  Google Scholar 

  3. Keating, S. E., Hackett, D. A., George, J. & Johnson, N. A. Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis, J. Hepatol. http://dx.doi.org/10.1016/j.jhep.2012.02.023.

  4. Neuschwander-Tetri, B. A. et al. Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease. Hepatology 52, 913–924 (2010).

    Article  CAS  Google Scholar 

  5. Musso, G., Cassader, M., Rosina, F. & Gambino, R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomized trials. Diabetologia 55, 885–904 (2012).

    Article  CAS  Google Scholar 

  6. Thoma, C., Day, C. P. & Trenell, M. I. Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review. J. Hepatol. 56, 255–266 (2012).

    Article  Google Scholar 

  7. Johnson, N. A. & George, J. Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease. Hepatology 52, 370–381 (2010).

    Article  CAS  Google Scholar 

  8. Centis, E., Marzocchi, R., Di Domizio, S., Ciaravella, M. F. & Marchesini, G. The effect of lifestyle changes in non-alcoholic fatty liver disease. Dig. Dis. 28, 267–273 (2010).

    Article  Google Scholar 

  9. Frith, J. et al. Potential strategies to improve uptake of exercise interventions in non-alcoholic fatty liver disease. J. Hepatol. 52, 112–116 (2010).

    Article  Google Scholar 

  10. Chalasani, N. et al. The diagnosis and management of non-alcoholic fatty liver disease. Hepatology http://dx.doi.org/10.1002/hep.25762.

Download references

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Correspondence to Joel E. Lavine.

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The authors declare no competing financial interests.

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Reynoso, E., Lavine, J. The role of exercise in treating NAFLD. Nat Rev Gastroenterol Hepatol 9, 368–370 (2012). https://doi.org/10.1038/nrgastro.2012.98

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