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T cells

A tissue checkpoint for TH2s

Nature Reviews Immunology volume 16, page 717 (2016)Cite this article

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Numerous diverse signals promote type 2 immune responses, which are characterized by interleukin-4 (IL-4), IL-5 and IL-13 production. However, the mechanisms that drive the production of these effector cytokines remain unclear. Reporting in Nature Immunology, Locksley and colleagues show that the production of effector cytokines by type 2 innate lymphoid cells (ILC2s) and T helper 2 (TH2) cells reflects the integration of a combination of tissue-derived cytokines.

ILC2s and effector TH2 cells complete their differentiation in affected tissues

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References

  1. Van Dyken, S. J. et al. A tissue checkpoint regulates type 2 immunity. Nat. Immunol. http://dx.doi.org/10.1038/ni.3582 (2016)

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Authors
  1. Olive Leavy
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Wynn, T. A. Type 2 cytokines: mechanisms and therapeutic strategies. Nat. Rev. Immunol. 15, 271–282 (2015)

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Leavy, O. A tissue checkpoint for TH2s. Nat Rev Immunol 16, 717 (2016). https://doi.org/10.1038/nri.2016.130

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