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Lymphocyte migration

T cells and DCs get it together

Nature Reviews Immunology volume 4, page 86 (2004)Cite this article

Mice were injected with fluorescence-labelled DCs into the footpad, and by the following day, DCs had accumulated in the PLNs. Lipopolysaccharide was co-administered with DCs to induce the expression of CC-chemokine receptor 7 (CCR7) by the DCs, which allows them to home to lymph nodes. Eighteen hours after DC injection, T-cell-receptor-transgenic CD8+ T cells were injected intravenously. Two hours after injection, the transgenic T cells had migrated to the PLNs and constituted 1–2% of T cells.

Where do the injected DCs localize in the PLNs? The authors found that many of the DCs localized around high endothelial venules (HEVs) — a site that allows the DCs to interact with T cells as they enter the node.

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References

ORIGINAL RESEARCH PAPER

  1. Mempel, T. R., Henrickson, S. E. & von Andrian, U. H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427, 154–159 (2004)

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FURTHER READING

  1. von Andrian, U. H. & Mempel, T. R. Homing and cellular traffic in lymph nodes. Nature Rev. Immunol. 3, 867–878 (2003)

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Authors
  1. Elaine Bell
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Bell, E. T cells and DCs get it together. Nat Rev Immunol 4, 86 (2004). https://doi.org/10.1038/nri1301

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