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Haematopoiesis

Death-defying factor identified

Nature Reviews Immunology volume 4, page 164 (2004)Cite this article

Shibayama et al. used an interleukin-3 (IL-3)-independent variant of a mouse IL-3-dependent cell line to isolate molecules that conferred resistance to apoptosis induced by IL-3 starvation. cDNA encoding anamorsin — a novel protein with no homology to any known anti-apoptotic molecule — was isolated from cells that survived IL-3 deprivation. The anti-apoptotic effect of this protein was confirmed by the observation that stable expression of anamorsin by the parental cell line and by a second IL-3-dependent cell line conferred resistance to apoptosis after IL-3 withdrawal.

In addition to IL-3, anamorsin expression was induced by other cytokines, including SCF and EPO, indicating that it probably has a general role in mediating the anti-apoptotic effects of cytokine exposure in vitro.

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ORIGINAL RESEARCH PAPER

  1. Shibayama, H. et al. Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive haematopoiesis. J. Exp. Med. 199, 581–592 (2004)

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  1. Karen Honey
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Honey, K. Death-defying factor identified. Nat Rev Immunol 4, 164 (2004). https://doi.org/10.1038/nri1320

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  • DOI: https://doi.org/10.1038/nri1320

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