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T-cell activation

CCL3 and CCL4 actively recruit CD8+ T cells

Nature Reviews Immunology volume 6, page 427 (2006)Cite this article

In this study, Castellino et al. set out to test the hypothesis that CD8+ T cells are actively recruited to DCs that are activated by CD4+ T cells. When immunocompetent mouse recipients of OT-I T cells and OT-II T cells (CD8+ and CD4+ T cells that express a T-cell receptor specific for a peptide consisting of amino-acid residues 257–264 and 323–339 of ovalbumin (OVA), respectively) were immunized with OVA257–264 in adjuvant on both flanks, equal numbers of OT-I T cells were detected in both draining lymph nodes. However, if OVA323–339 was administered to one flank (with either OVA257–264 and adjuvant, or adjuvant alone being concomitantly administered to both flanks), the accumulation of OT-I T cells was greater in that draining lymph node than in the contralateral lymph node.

Furthermore, intravital two-photon microscopy showed that, in the presence of OT-II T cells, OT-I T cells came into contact with DCs pulsed with OVA323–339 more often than with unpulsed control DCs.

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ORIGINAL RESEARCH PAPER

  1. Castellino, F. et al. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction. Nature 440, 890–895 (2006)

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  1. Karen Honey
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Honey, K. CCL3 and CCL4 actively recruit CD8+ T cells. Nat Rev Immunol 6, 427 (2006). https://doi.org/10.1038/nri1862

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