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Signalling

Conjugating enzyme IDed

Nature Reviews Immunology volume 6, page 629 (2006)Cite this article

Previous studies indicated that UBC13 might be important for the polyubiquitylation of TRAF2 (tumour-necrosis factor (TNF)-receptor-associated factor 2) and TRAF6, an essential step in the transduction of signals from immune receptors to the key transcription factor nuclear factor-κB (NF-κB). To determine the exact mechanism by which UBC13 influences immune signalling, the authors generated mice in which the expression of UBC13 could be conditionally ablated. Using these mice, the authors showed that UBC13 has an important role in the development of marginal-zone B cells and peritoneal CD5+ B1 cells, as well as in the activation, cell-cycle progression and viability of splenic B cells, and in the generation of in vivo humoral responses.

To understand the role of UBC13 in response to Toll-like receptor (TLR) activation, UBC13-deficient peritoneal macrophages were stimulated with various TLR ligands. Less TNF, interleukin-6 (IL-6) and IL-12p40 was produced by these cells than by UBC13-sufficient cells. Surprisingly, activation of NF-κB was not markedly affected. However, in the absence of UBC13, activation of members of the mitogen-activated protein kinase (MAPK) family was severely impaired in response to various stimuli, including TLR ligands and IL-1β, but not TNF.

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ORIGINAL RESEARCH PAPER

  1. Yamamoto, M. et al. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nature Immunol. 23 July 2006 (doi:10.1038/ni1367)

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Authors
  1. Olive Leavy
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Leavy, O. Conjugating enzyme IDed. Nat Rev Immunol 6, 629 (2006). https://doi.org/10.1038/nri1930

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  • DOI: https://doi.org/10.1038/nri1930

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