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T cell activation

Fine-tuning the immunological synapse

Nature Reviews Immunology volume 9, pages 306–307 (2009)Cite this article

...the actin-based motor protein myosin IIA has a central role in the formation and persistence of the immunological synapse...

TCR engagement results in the immediate actin-dependent formation of TCR microclusters and recruitment of signalling components to the outer parts of the T cell–APC contact area. The TCR microclusters then move to the centre of the contact area and combine to form the central supramolecular activation cluster (cSMAC) of the immunological synapse. This inwards (centripetal) movement of the microclusters sustains TCR signalling and depends on filamentous actin. But how the microclusters are coupled to actin to result in this centripetal movement is not known.

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ORIGINAL RESEARCH PAPER

  1. Ilani, T. et al. T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nature Immunol. 6 Ap 2009 (doi:10.1038/ni.1723)

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  1. Olive Leavy
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Leavy, O. Fine-tuning the immunological synapse. Nat Rev Immunol 9, 306–307 (2009). https://doi.org/10.1038/nri2557

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  • DOI: https://doi.org/10.1038/nri2557

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