Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Lymphoid organogenesis

Lymph node stroma and adipocytes: the link

Nature Reviews Immunology volume 12, page 683 (2012)Cite this article

Subjects

Adipocyte progenitors are derived from mesenchymal stem cells and express the transmembrane marker PREF1 (also known as DLK1). Imaging of embryonic lymph nodes and their associated fat pads revealed the presence of PREF1+ cells co-expressing lymphoid stromal markers in lymph node anlagen. Moreover, embryonic adipocyte progenitors responded to lymphotoxin-β receptor (LTβR) stimulation, which has a key role in lymph node development, by downregulating their adipogenic transcriptional programme. LTβR-dependent reprogramming of adipocyte progenitors involved the non-canonical NF-κB pathway, and after LTβR stimulation both embryonic and adult adipocyte progenitors migrated from fat pads to lymph node anlagen and expressed lymphocyte pro-survival factors. So, adult adipocyte progenitors may also drive the formation of tertiary lymphoid structures in the presence of lymphotoxin.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Bénézech, C. et al. Lymphotoxin-β receptor signaling through NF-κB2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells. Immunity 30 Aug 2012 (doi:10.1016/j.immuni.2012.06.010)

Download references

Authors
  1. Maria Papatriantafyllou
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Papatriantafyllou, M. Lymph node stroma and adipocytes: the link. Nat Rev Immunol 12, 683 (2012). https://doi.org/10.1038/nri3315

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nri3315

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing