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Lymphocyte migration

Modes of transport

Nature Reviews Immunology volume 1, page 6 (2001)Cite this article

To study the physiological role of DOCK2, Fukui and colleagues generated DOCK2−/− mice. The cellularity of secondary lymphoid organs was reduced in the DOCK2−/− mice, although the proportion of monocytes was increased, indicating that lymphocyte homing might be impaired. To investigate the ability of lymphocytes to migrate to lymph nodes or spleen, fluorescently labelled DOCK2−/− and DOCK2+/− CD4+ T cells or B cells were injected into wild-type mice. The migratory capacity of the DOCK2−/− cells was considerably reduced in comparison with the DOCK2+/− cells.

Next, the authors analysed the movement of DOCK2−/− splenic T and B cells in response to several chemokines. Whereas T and B cells from DOCK2+/− mice migrated in response to secondary lymphoid tissue chemokine (SLC), stroma-derived factor 1 (SDF-1) and B-lymphocyte chemoattractant (BLC), DOCK2−/− cells showed no response to these chemokines.

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ORIGINAL RESEARCH PAPER

  1. Fukui, Y. et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 412, 826–831 (2001)

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Authors
  1. Jenny Buckland
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Buckland, J. Modes of transport. Nat Rev Immunol 1, 6 (2001). https://doi.org/10.1038/35095531

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  • DOI: https://doi.org/10.1038/35095531

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