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Infectious disease

Fungal restriction of renal T cell migration

Nature Reviews Immunology volume 14, page 779 (2014)Cite this article

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Although CD4+ T cells, particularly T helper 17 (TH17) cells, have a crucial role in antifungal immunity, it has been thought that T cells are redundant for the control of renal Candida albicans infection. Drummond et al. characterized the T cell response during systemic candidiasis and found that the antigen-specific CD4+ T cell response in the renal lymph nodes was increased at day 3 post infection with the C. albicans strain Calb-Ag. However, this response became blunted at day 6. Furthermore, antigen-specific CD4+ T cells did not migrate to the infected kidneys, although CD8+ T cell recruitment was not affected. Enforced CD4+ T cell migration using antigen-loaded immunoliposomes resulted in the accumulation of antigen-specific TH17 cells and decreased fungal burdens in the kidneys. Although the reason for the defective migration of CD4+ T cells to the kidneys remains to be determined, restoring tissue CD4+ T cell responses helps to control fungal growth in the kidneys.

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References

  1. Drummond, R. A. et al. Failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis. J. Immunol. http://dx.doi.org/10.4049/jimmunol.1401675 (2014)

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  1. Olive Leavy
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Leavy, O. Fungal restriction of renal T cell migration. Nat Rev Immunol 14, 779 (2014). https://doi.org/10.1038/nri3782

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