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HIV

On the road to an HIV vaccine?

Nature Reviews Immunology volume 15, page 202 (2015)Cite this article

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In recent years, a large panel of HIV broadly neutralizing antibodies has been described and adeno-associated virus (AAV)-expressed broadly neutralizing antibodies can protect humanized mice from an HIV-1 challenge. However, a proportion of HIV-1 isolates remain resistant to even the best broadly neutralizing antibodies. So, broader and more potent inhibitors of HIV are needed.

CD4-Ig is an immunoadhesin of CD4 that is comprised of CD4 domains 1 and 2 fused to the Fc domain of IgG1. This molecule irreversibly inactivates the HIV envelope glycoprotein (Env; which is involved in recognizing the CD4 receptor) and neutralizes most HIV isolates. However, its affinity for Env is lower than those of broadly neutralizing antibodies and it can promote infection. The CCR5-mimetic sulfopeptide CCR5mim1 is derived from the HIV-1 neutralizing antibody E51 and specifically binds the CCR5-binding region of Env.

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References

  1. Gardner, M. R. et al. AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. Nature 519, 87–91 (2015)

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  1. Olive Leavy
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Kwong, P. D., Mascola, J. R. and Nabel, G. J. Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning. Nature Rev. Immunol. 13, 693–701 (2013)

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Leavy, O. On the road to an HIV vaccine?. Nat Rev Immunol 15, 202 (2015). https://doi.org/10.1038/nri3836

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