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Vaccines

HIV: effective protection?

Nature Reviews Immunology volume 2, page 7 (2002)Cite this article

This study is the first to directly compare mucosal and systemic immunization with the same vaccine in primates, and to assess the contribution of mucosal CTLs in clearing the mucosal viral reservoir. The peptide vaccine consisted of a mixture of four peptides, each containing a cluster of overlapping HIV-1 helper epitopes, and various CTL epitopes from simian immunodeficiency virus (SIV) Gag and Pol. Macaques were immunized either intra-rectally or subcutaneously in two cycles of four vaccine immunizations. In intra-rectally immunized animals, CTL responses were detected in both mucosal lymphoid sites and systemic lymphoid sites. By contrast, subcutaneous immunization predominantly elicited CTLs in the systemic compartment.

At 8 weeks after the immunizations, macaques were given an additional dose of vaccine, and 2 weeks later, were challenged intra-rectally with a pathogenic strain of simian/HIV, SHIV-Ku2. Animals immunized intra-rectally, in contrast to subcutaneously immunized animals, had plasma viral loads which rapidly fell below the level of detection.

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ORIGINAL RESEARCH PAPER

  1. Belyakov, I. M. et al. Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques. Nature Med. 7, 1320–1326 (2001).

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  1. Elaine Bell
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Bell, E. HIV: effective protection?. Nat Rev Immunol 2, 7 (2002). https://doi.org/10.1038/nri707

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  • DOI: https://doi.org/10.1038/nri707

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