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HIV

FEZ blockade for HIV

Nature Reviews Microbiology volume 3, page 519 (2005)Cite this article

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The authors set out to identify new host alleles that mediate antiretroviral defence by mutagenizing rat fibroblast cells and selecting for resistance to Moloney murine leukaemia viruses (MLVs). The phenotypes of the different virus-resistant mutant cell lines that have been characterized reveal that the host might use different mechanisms in a multistep process to resist virus infection.

One mutant cell line, R3-2, which was 1,000-fold more resistant to MLV than the unmutagenized parental cells, was also resistant to HIV-1, and the block in virus replication was post-entry. Although reverse transcription of incoming viral RNA took place, new viral DNA was retained in the cytoplasm, instead of being transported into the nucleus to integrate into the cellular genome. Naghavi et al. used an array-based approach to probe the basis of retroviral resistance in R3-2 cells.

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Change history

  • 26 March 2018

    This article was initially published with an incorrect DOI. A new DOI has been assigned and registered at Crossref, and has been corrected in the article.

ORIGINAL RESEARCH PAPER

  1. Naghavi, M. H., Hatziioannou, T., Gao, G. & Goff, S. P. Overexpression of fasciculation and elongation protein ζ-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells. Genes Dev. 19, 1105–1115 (2005)

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Authors
  1. Susan Jones
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Jones, S. FEZ blockade for HIV. Nat Rev Microbiol 3, 519 (2005). https://doi.org/10.1038/nrmicro1199

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  • DOI: https://doi.org/10.1038/nrmicro1199

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