No Nogo — grow/no grow?

Jones, Rachel

doi:10.1038/nrn1135

Research Highlight
Published: 01 June 2003

Repair

No Nogo — grow/no grow?

Rachel Jones

Nature Reviews Neuroscience volume 4, page 429 (2003)Cite this article

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Evidence from several studies has led to the view that Nogo, with other myelin-associated proteins, inhibits outgrowth of axons. Perhaps if this inhibition could be blocked or removed, injured axons in the central nervous system could regenerate. Three groups have generated mice that lack one, two or all three isoforms of Nogo, to see whether these mice show improved regeneration of central axons.

Nogo-A is the main isoform found in oligodendrocytes, so it has attracted the most attention in studies of regeneration. The first study, by Kim et al., used mice with a mutation that prevents expression of Nogo-A and B. After spinal cord injury in young adult mice, they found that the knockout mice showed increased sprouting of corticospinal axons and also improvements in motor function — a promising result.

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ORIGINAL RESEARCH PAPERS

Kim, J. -E. et al. Axon regeneration in young adult mice lacking Nogo-A/B. Neuron 38, 187–199 (2003)
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Simonen, M. et al. Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 38, 201–211 (2003)
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Zheng, B. et al. Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 38, 213–224 (2003)
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