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Development

Cell patterning by preferential adhesion

Nature Reviews Neuroscience volume 6, page 585 (2005)Cite this article

Cell–cell adhesion is essential for morphogenesis, the process by which single cells are shaped and assembled into complex tissues and organs. But it is not clear how the multitude of cell surface molecules involved in cell adhesion influences cell fates and tissue patterning.

Bao and Cagan looked at adhesion processes in Drosophila eye development. At late larval stages, the eye disc, a monolayer epithelium, differentiates to form an array of 'unit eyes' or 'ommatidia', each of which contains photoreceptor cells, lens-secreting cone cells and primary pigment cells. Undifferentiated cells between these ommatidia, the interommatidial precursor cells (IPCs), then undergo morphogenetic movements and differentiate to create a hexagonal lattice of secondary and tertiary pigment cells and mechanosensory bristles.

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References

ORIGINAL RESEARCH PAPER

  1. Bao, S. & Cagan, R. Preferential adhesion mediated by Hibris and Roughest regulates morphogenesis and patterning in the Drosophila eye. Dev. Cell 8, 925–935 (2005)

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FURTHER READING

  1. Hayashi, T. & Carthew, R. Surface mechanics mediate pattern formation in the developing retina. Nature 431, 647–652 (2004)

    Article  CAS  Google Scholar 

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Authors
  1. Rebecca Craven
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Craven, R. Cell patterning by preferential adhesion. Nat Rev Neurosci 6, 585 (2005). https://doi.org/10.1038/nrn1735

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  • DOI: https://doi.org/10.1038/nrn1735

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