Exploring profilin

Wiedemann, Claudia

doi:10.1038/nrn2182

Research Highlight
Published: July 2007

Neurotransmission

Exploring profilin

Claudia Wiedemann

Nature Reviews Neuroscience volume 8, page 495 (2007)Cite this article

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There are four mammalian profilin isoforms, all of which are G-actin binding proteins. Profilins are implicated in the actin dynamics that control membrane trafficking events such as vesicle endo- and exocytosis. Brain cells express profilin 2, but the role of this protein in brain function is not well understood. The authors therefore used profilin 2-knockout mice (Pfn2^−/−) to investigate the effects of profilin 2 at anatomical, electrophysiological and behavioural levels.

Surprisingly, they found that Pfn2^−/− mice displayed normal development and brain anatomy. Learning and memory, long-term potentiation (LTP) and long-term depression (LTD) were not impaired in Pfn2^−/− mice when compared with control mice. These results suggest that profilin 2 is not required for development, synaptic plasticity or learning and memory.

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ORIGINAL RESEARCH PAPER

Boyl, P. P. et al. Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behaviour. EMBO J. 31 May 2007 (doi:10.1038/sj.emboj.7601737)
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