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Affective disorders

Resisting stress

Nature Reviews Neuroscience volume 8, page 909 (2007)Cite this article

The authors subjected mice to social defeat for 10 days by introducing each animal daily into the cage of an aggressive mouse until the 'intruder' showed submissive behaviour. They then tested the social interaction level of all defeated mice and divided them into two groups: one consisting of 'susceptible' mice that showed reduced social interaction and the other consisting of 'resilient' mice that demonstrated similar interaction to control mice.

Susceptible and resilient mice did not differ in body weight, social interaction or exploration measures before the chronic stress, but afterwards the susceptible animals were lighter and displayed social withdrawal, anhedonia and altered reward processing.

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ORIGINAL RESEARCH PAPER

  1. Krishnan, V. et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131, 391–404 (2007)

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  1. Leonie Welberg
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Welberg, L. Resisting stress. Nat Rev Neurosci 8, 909 (2007). https://doi.org/10.1038/nrn2279

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