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Proprioception

Sensational mechanics

Nature Reviews Neuroscience volume 11, page 665 (2010)Cite this article

Subjects

Cheng et al. showed the importance of TRPN1 for proprioception in Drosophila melanogaster. Using a green fluorescent protein construct, the authors showed expression of the channel in subsets of peripheral sensory neurons that had previously been implicated in coordinating locomotion.

TRPN1-null larvae crawled more slowly than wild-type larvae, suggesting impaired proprioception given the loss of TRPN1 in sensory neurons, and TRPN1-null adult flies exhibited uncoordinated leg and wing movements, and were unable to walk or fly. These defects were rescued by expression of TRPN1 under the control of sensory-neuron-specific promoters.

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References

ORIGINAL RESEARCH PAPERS

  1. Cheng, L. E. et al. The role of the TRP channel NompC in Drosophila larval and adult locomotion. Neuron 67, 373–380 (2010)

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  2. Kang, L. et al. C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. Neuron 67, 381–391 (2010)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

FURTHER READING

  1. Li, W. et al. A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue. Nature 440, 684–687 (2006)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors
  1. Katie Kingwell
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Kingwell, K. Sensational mechanics. Nat Rev Neurosci 11, 665 (2010). https://doi.org/10.1038/nrn2922

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