Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Neurogenesis

Pathways for population balance

Nature Reviews Neuroscience volume 11, page 731 (2010)Cite this article

Subjects

The authors overexpressed human EGFR in mice and showed that it was present in NPCs but absent from NSCs. These mice, and mice infused with EGF in the lateral ventricle, have more NPCs but fewer NSCs in the SVZ. Enhanced EGFR signalling was also shown to upregulate genes involved in neurogenesis and to downregulate Notch signalling elements, indicating a potential interaction between Notch 1, which was mainly detected in the SVZ NSCs, and EGFR.

The NSCs in the SVZ of human-EGFR-expressing mice showed morphological defects that could be rescued by overexpressing constitutively active Notch 1. In addition, NPC depletion in the SVZ increased the numbers of NSCs in the SVZ of human-EGFR-expressing mice, and these NSCs expressed higher levels of Notch 1, suggesting an interaction between the two cell populations. Co-culture experiments confirmed that there is contact-mediated regulation between the cell types, as Notch signalling in SVZ NSCs and NSC proliferation were reduced in the presence of human-EGFR-expressing NPCs. These data indicate that NPCs inhibit NSC proliferation through an EGFR–Notch 1 interaction.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Aguirre, A., Rubio, M. E. & Gallo, V. Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature 467, 323–327 (2010)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Copy Editor, Nature Reviews Molecular Cell Biology,

    Debbie Walker

Authors
  1. Debbie Walker
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Walker, D. Pathways for population balance. Nat Rev Neurosci 11, 731 (2010). https://doi.org/10.1038/nrn2933

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrn2933

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing