Does multiple sclerosis originate in the gut?

Yates, Darran

doi:10.1038/nrn3150

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Published: 18 November 2011

Neuroimmunology

Does multiple sclerosis originate in the gut?

Darran Yates

Nature Reviews Neuroscience volume 12, page 706 (2011)Cite this article

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Autoreactive T and B cells may have important roles in multiple sclerosis, but what triggers autoreactivity is unclear. Here, the authors examined a relapsing–remitting variant of spontaneously developing murine experimental autoimmune encephalomyelitis (EAE). In this multiple sclerosis model, disease is driven by T cells that recognize a myelin autoantigen, and by recruited B cells that produce autoantibodies. Interestingly, relapsing–remitting mice that had been brought up in a germ-free environment, and hence had no commensal gut microbes, did not develop EAE and had impaired B-cell recruitment, suggesting that such microbes may have a role in multiple sclerosis.

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ORIGINAL RESEARCH PAPER

Berer, K. et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 26 Oct 2011 (doi:10.1038/nature10554)
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