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Neural development

Nogo to synapse formation

Nature Reviews Neuroscience volume 13, page 221 (2012)Cite this article

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A new study reveals that Nogo receptors (NgRs) have key roles in restricting synapse formation. Wills et al. showed that loss of all three NgRs in mice promoted excitatory synapse formation, whereas overexpression of NgR1 in hippocampal slices decreased synaptic density. Furthermore, they showed that NgRs seemed to specifically limit synapse addition, partly through limiting dendritic growth. Interestingly, Wills et al. found that NgR expression was downregulated by neuronal activity, possibly facilitating activity-dependent synapse formation.

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ORIGINAL RESEARCH PAPER

  1. Wills, Z. P. et al. The Nogo receptor family restricts synapse number in the developing hippocampus. Neuron 73, 466–481 (2012)Article

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  1. Darran Yates
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Yates, D. Nogo to synapse formation. Nat Rev Neurosci 13, 221 (2012). https://doi.org/10.1038/nrn3219

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